US giant Bechtel and Japanese firm JGC Corporation are lined up to build a nuclear power station on the Isle of Anglesey.
Hitachi – the parent company of Wylfa Newydd developer Horizon – said it was talking to the two firms about forming a delivery team for the massive project.
The news comes days after energy giant EDF awarded more than £1bn of contracts on the Hinkley Point C project as the new nuclear programme gains momentum.
A Hitachi spokesman said: “We are in exclusive discussions with two companies – Bechtel and JGC corporation – regarding a potential role in the engineering, procurement and construction delivery team for Wylfa Newydd.
“It is our intention to put together a delivery team which will build on our knowledge of deploying the Advanced Boiling Water Reactor, adding extensive global experience.
“This progress will also pave the way for significant involvement of UK firms throughout the supply chain”.
Hitachi and Horizon are working through a process to secure approval for their plans, and construction could begin before the end of this decade.