The £1.7bn Royal Albert Dock redevelopment has moved a step forward, after The Greater London Authority gave the go-ahead to developers ABP.
Work on the 14ha business district is expected to start later this year, with the first phase completed in 2018.
The project includes upgrading the local transport infrastructure including Docklands Light Railway and Crossrail stations.
Mayor of Newham Sir Robin Wales said: “The ABP development will bring further investment in to east London, including thousands of jobs and opportunities for Newham residents within high-tech businesses as well as construction industries from at home and abroad.
“ABP is a significant part of the Royal Docks transformation, which will see the revival of the waterfront and reinstate the docks as the heart of London’s industry.”