The voluntary body which includes Surrey County Council, the Highways Agency, bus and rail firms and business groups will "pool risk, resources and expertise" to deliver integrated schemes.
The newly formed body will start with major schemes in Guildford and Reigate/Redhill including major bus/rail interchanges, a single transport information system, park and ride, road safety schemes and improved access to Heathrow and Gatwick airports.
"Public transport in Surrey is not as joined up as it could be," said newly appointed head of Transport for Surrey Iain Reeve.
"A wide range of organisations are responsible for different aspects of the system, leading to waste and duplication.
"By bringing these different bodies together and identifying better ways of working, TfS aims to provide a more integrated transport system, in a similar way to Transport for London."
He added: "People wanting to travel in Surrey need a single point of contact like this body."
TfS is the latest body to follow the Transport for London model after similar partnerships were set up including Solent Transport and Transport for Tees Valley.
The Local Government Association's Innovation Forum has provided funding for TfS and has signalled that it would fund other initiatives elsewhere in the UK.