The A1 road in North Yorkshire will be closed for 34 hours this weekend as Fort Bridge is replaced.
The bridge is being replaced as part of the A1 Leeming to Barton major road scheme.
The original Fort Bridge was demolished last November to allow space for an extra lane to be added to the road as part of the A1 upgrade.
The £380M Highways England project, which began in 2014, has replaced the existing dual carriageway with a new three-lane motorway that will open next year.
The A1 will be closed from 8pm on Friday 7 October until 6am on Sunday 9 October in both directions between Junction 51 (Leeming Bar) and Scotch Corner.
A 500t crane will lift the steel beams weighing 40t each into place during the closure to create a new bridge at Catterick. Highways England said that once the new beams have been installed, work will begin on constructing the concrete bridge deck.
The bridge links Catterick Garrison in the west to the communities of Catterick and Brompton in the east.
“This is a significant milestone for the scheme and a complex piece of engineering, which is why it is essential we close sections of the A1,” said Highways England project manager Tom Howard.
“When the whole project is complete, the section of the A1 between Leeming and Barton will be upgraded to a three-lane motorway, tackling congestion and improving journey times.”
Additional work will also be taking place during the closure, including resurfacing one of the slip roads at the Scotch Corner junction.
The new bridge is due to open to traffic next year.
Once completed, the A1 Leeming to Barton scheme will create a continuous motorway-standard route between London and Newcastle, including the M1 and A1M. Highways England said that it would also improve journey times and increase safety.