Wandsworth Council has submitted a planning application for the proposed £5.5bn regeneration plan around the iconic Battersea Power Station.
3,700 homes alongside offices, shops and restaurants will be built on the 40-acre site, which has been the subject on a year-long consultation.
Developer Treasury Holdings UK spokesman Rob Tincknell, said: “We are extremely confident that two years of detailed discussions mean that this masterplan represents the aspirations and concerns of all the stakeholders involved, not least the Battersea community.”
The power station - which closed in 1983 - will house a conference centre under the plan, and its four famous chimneys will be restored.
Two turbine halls and the station’s control rooms will be open to the public and a six-acre riverside park will be developed on the riverside north of the building.
Leader of Wandsworth council Councillor Edward Lister, said: “The wider area covers more than 450 acres and is without doubt the capital’s biggest regeneration opportunity.
Outline planning permission have already been awarded for the new US Embassy at a separate site in the area, he added:
“These two important projects are hugely symbolic and demonstrate the scale of the commitment to this new urban quarter in the heart of London,” he said.